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That said, human safety data currently consists of only three small studies with no randomized controlled trials, and the longest follow-up spans just 6 to 12 months

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identified six serum metabolites that could specifically predict the need for imaging and reported that reductions in 2-aminobutyric acid (generated in the biosynthesis of the BCAA isoleucine) and increases in the ketone body acetoacetic acid corresponded to positive CT findings [41]

For topical stuff, some people get mild irritation if they jump straight into strong serums